TRANSLATIONAL PHYSIOLOGY Repolarization abnormalities and afterdepolarizations in a canine model of sudden cardiac death
نویسندگان
چکیده
Arun Sridhar, Yoshinori Nishijima, Dmitry Terentyev, Radmila Terentyeva, Rebecca Uelmen, Monica Kukielka, Ingrid M. Bonilla, Gail A. Robertson, Sandor Györke, George E. Billman, and Cynthia A. Carnes Davis Heart and Lung Research Institute, Biophysics Program, Department of Physiology and Cell Biology, College of Pharmacy, Ohio State University, Columbus, Ohio; and Department of Physiology, University of Wisconsin, Madison, Wisconsin
منابع مشابه
Repolarization abnormalities and afterdepolarizations in a canine model of sudden cardiac death.
Ventricular tachyarrhythmias are the most common cause of sudden cardiac death (SCD); a healed myocardial infarction increases the risk of SCD. We determined the contribution of specific repolarization abnormalities to ventricular tachyarrhythmias in a postinfarction model of SCD. For our methods, we used a postinfarction canine model of SCD, where an exercise and ischemia test was used to stra...
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The high incidence of sudden death in heart failure may reflect an increased propensity to abnormal repolarization and long Q-T interval-related arrhythmias. If so, cells from failing hearts would logically be expected to exhibit a heightened susceptibility to early afterdepolarizations (EAD). We found that midmyocardial ventricular cells isolated from dogs with pacing-induced heart failure exh...
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The risk of sudden cardiac death is increased following myocardial infarction. Exercise training reduces arrhythmia susceptibility, but the mechanism is unknown. We used a canine model of sudden cardiac death (healed infarction, with ventricular tachyarrhythmias induced by an exercise plus ischemia test, VF+); we previously reported that endurance exercise training was antiarrhythmic in this mo...
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Diabetes mellitus increases the risk for cardiac dysfunction, heart failure, and sudden death. The wide array of neurohumoral changes associated with diabetes pose a challenge to understanding the roles of specific pathways that alter cardiac function. Here, we use a mouse model with cardiomyocyte-restricted deletion of insulin receptors (CIRKO, cardiac-specific insulin receptor knockout) to st...
متن کاملEarly afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve
AIMS Acute ischemia is a major cause of sudden arrhythmic death, further promoted by potassium current blockers. Macro-reentry around the ischemic region and early afterdepolarizations (EADs) caused by electrotonic current have been suggested as potential mechanisms in animal and isolated cell studies. However, ventricular and human-specific arrhythmia mechanisms and their modulation by repolar...
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تاریخ انتشار 2008